Monday 3 October 2016

Cause of Crohn's Disease: Gut Fungus Now Suspected By Agata Blaszczak-Boxe, Contributing Writer

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Cause of Crohn's Disease: Gut Fungus Now Suspected
The small intestine is about as big around as a middle finger, but it is about 22 feet (6.7 meters) long.
Credit: Sebastian Kaulitzki | Shutterstock

People with the inflammatory condition Crohn's disease may have a higher level of a certain fungus in their gut, a new study finds.
Scientists have known that gut bacteria may contribute to the development of Crohn's, but the new study finds that this fungus may also play a role in the condition.
The findings could lead to new treatments for people with the disease, who may have such symptoms as severe abdominal pain, weight loss, fatigue and diarrhea. [5 Things Your Poop Says About Your Health]
"We already know that bacteria, in addition to genetic and dietary factors, play a major role in causing Crohn's disease," study co-author Mahmoud A. Ghannoum, director of the Center for Medical Mycology at Case Western Reserve, said in a statement. Previous research has shown that people with Crohn's have an abnormal response to certain bacteria that live in the gut, he said. "While most researchers focus their investigations on these bacteria, few have examined the role of fungi, which are also present in everyone's intestines," Ghannoum added.
In the study, the researchers analyzed the microorganisms found in fecal samples from 20 people with Crohn's, 28 of their relatives without the disease, and 21 people without Crohn's who were not related to the 20 people with Crohn's or their relatives. All of the participants were residents of Belgium or northern France.
The researchers found that the people with Crohn's disease had significantly higher levels of two types of bacteria, called Escherichia coliand Serratia marcescens, and one fungus, called Candida tropicalis, compared with their healthy relatives and the other people in the study who did not have the disease, according to the study, published Sept. 20 in the journal mBio.
Although previous research in mice has suggested that this fungus may be involved in Crohn's, this is the first time it has been linked to the condition in people, the researchers said.
Moreover, when the researchers examined these bacteria and fungus, they found that the three microorganisms worked together to form a so-called biofilm — a thin, sticky layer of microorganisms — that attaches itself to a portion of the gut. This biofilm could trigger the inflammation that causes the symptoms of Crohn's disease, the researchers said. [5 Ways Gut Bacteria Affect Your Health]
The new study "moves the field forward," said Dr. Arun Swaminath, director of the inflammatory bowel disease program at Lenox Hill Hospital in New York City, who was not involved in the study. "The really neat thing they have done is to show how [these microorganisms] actually interact together," to form the biofilm, he said.
However, the study was conducted in a small group of patients in France and Belgium, and more research is needed to see if these findings would apply to patients in other countries, Swaminath said.
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Where Did Satan Come From? By Laura Geggel, Senior Writer


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Where Did Satan Come From?
What's this guy's story?
Credit: bastetamon | Shutterstock.com
The devil goes by many names — Satan, the Prince of Darkness, Beelzebub and Lucifer to name a few — but besides this list of aliases, what do people really know about the brute? That is, how did the story of Satan originate?
Many ancient religions have scriptures detailing the struggle between good and evil. For instance, in the Zoroastrian religion, one of the world's earliest, the supreme deity, Ormazd, created two entities: the chaotic and destructive spirit Ahriman and his beneficent twin brother, Spenta Mainyu, said Abner Weiss, a psychologist and the rabbi at the Westwood Village Synagogue in Los Angeles.
"The ancient world struggled with the coexistence of good and evil," Weiss told Live Science. "They hypothesized a kind of demonic, divine force that was responsible for evil, arising out of the notion that a good god could not be responsible for bad things." [Gallery: Sun Gods and Goddesses]
However, Satan was not a prominent figure in Judaism. In Hebrew scripture, a demon-like figure appears only in the Book of Job. In that book, an "adversary" or "tempter" asks God whether the prosperous man Job would continue to praise God after losing everything. God takes up the challenge, and strips Job of his wealth and family, leaving the man wondering why such a horrible fate befell him.
But in this story, God wields more power than this adversary; as such, this evil tempter challenges God, who then takes away Job's fortune, Weiss said.
"[Judaism] found the notion of God having to share authority as limiting the omnipotence and even the omniscience of God," Weiss said. "And therefore, Satan was never personified as a source of evil that was equally powerful."
But Satan did become a part of certain Jewish sects beginning around the time of the Common Era, when Jesus was born, Weiss noted. Moreover, Judaism's mystical teachings, called the Kabbalah, mention a light side and a dark side, but the dark side is never given equal power to the light, Weiss said.
Any Sunday school student can tell you that Satan is a fallen angel, but this fall actually isn't described in the New Testament, or the Christian bible, said Jerry Walls, a professor of philosophy at Houston Baptist University and author of "Heaven, Hell and Purgatory: Rethinking the Things That Matter Most" (Brazos Press, 2015).
However, Satan suddenly appears in the gospels as the tempter of Jesus, with nary an introduction of how the evil presence got there. So, Christian theologians have come to this conclusion: If God created the universe, and everything God creates is good, then Satan must have been something good that went bad, Walls said.
"The only thing that can go bad by itself is a free being," Walls said. "Since there was evil before human beings came on the scene, the inference is[Satan] must have been a fallen angel."
There are other references to Satan in the Bible, depending on different interpretations. The Hebrew Bible has two passages about people who aren't respectful toward God. In these passages, Isaiah 4 and Ezekiel 28, human rulers make outrageous boasts, and some Christians interpret these actions as expressions of Satan, Walls said.
Moreover, the gospel of Paul in the New Testament refers to the snake from the Garden of Eden as Satan, though the snake isn't described that way in Genesis, Walls said. In this sense, the snake and Satan can be seen as tempters that try to get people to disobey God, but aren't always successful, Walls said. [Spooky! Top 10 Unexplained Phenomena]
"The first Adam fell to the temptation of Satan," Walls said. "Christ is described as the second Adam, who successfully resisted temptation."
Satan can also emerge as the enemy — the "other," or an "outside" group.
"I thought of Satan as a kind of a joke, kind of a throwaway character," said Elaine Pagels, a professor of religion at Princeton University and author of "The Origin of Satan" (Random House, 1995). "In the Book of Job, he's practically a device to explain what happened to Job."
The Hasids, a Jewish sect whose name translates into "The Holy Ones," were the first group in Judeo-Christian history to seriously discuss Satan, she said. The Hasids lived just before the Common Era and didn't like how the Romans and some of their Jewish collaborators ruled their country, Pagels said.
So, the Hasids withdrew from Jewish society and began preaching about the end of times, when God would destroy all of the evil people, "which meant all of the Romans and all of the Jews who cooperated with them," Pagels said.
The Hasids took a radical position: They said that they were following God, while their enemies had turned to the dark side, possibly without even knowing it. "So now, it's the 'Sons of God' against the 'Sons of Darkness,'" Pagels said. "It's a split Jewish group."
At this point of her research, Pagels had an epiphany, she said: The concept of Satan emerges when communities split. Radical groups want a clean break between themselves and their enemies, and so they describe their enemies as Satan, as devils who will one day face God's wrath.
"I realized that when people talk about Satan — like if somebody says, 'Satan is trying to take over this country' — they're not thinking of somesupernatural battle up there in the sky," Pagels said. "They can give you names and addresses. They know whom they're talking about."
For instance, extremists might say, "America is the Great Satan." That's because "when people talk about Satan, they're talking about people, too," Pagels said.
The Hasids likely had a big influence on early Christianity, because Jesus and John the Baptist preached similar ideas to those of the Hasids. That is, they said that the end of the world was coming and that God wouldn't tolerate evil people, Pagels said. This meant the Romans and the people working with them, she said. [Supernatural Powers? Tales of 10 Historical Predictions]
Turning an enemy into Satan is useful, she added. It suggests that "our opponents are not just people we disagree with — they're bad. You can't negotiate with them. You can't do anything with them, because they're essentially evil."
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Why Did Yahoo Take So Long to Disclose Security Breach?

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Why Did Yahoo Take So Long to Disclose Security Breach?
The Yahoo data breach affected more than 500 million users. Here, Yahoo's Marrissa Mayer, president and CEO.
Credit: Ethan Miller/Getty Images
This article was originally published at The Conversation. The publication contributed the article to Live Science's Expert Voices: Op-Ed & Insights.
In late September, Yahoo announced that at least 500 million user accounts had been compromised. The data stolen included users’ names, email addresses, telephone numbers, dates of birth and encrypted passwords, but not credit card data. Large data breaches have become increasingly common: Just in 2016 we have found out about Yahoo’s breach as well as the LinkedIn hack (compromising 167 million accounts) and the MySpace breach (360 million accounts).
The Yahoo breach affected more users than the other two, but all of them share a crucial element: They were announced to the public years after the fact. The LinkedIn hack happened in 2012MySpace was breached in 2013 and Yahoo was hacked in 2014. Not until 2016 did users of the three sites found out their information had been stolen.
When personal information is stolen, rapid response is important. Customers need to change their passwords, and take other steps to protect their identity, including securing bank accounts and credit records. If people don’t know a breach has occurred and that they need to take these protective steps, they remain vulnerable.
So why does it take such a long time for companies to disclose that they have been hacked? It’s not as simple as you might think – or hope.
It’s not yet clear when Yahoo learned about its attack, though in this case the timing is questionable. A news article published on August 1 quoted a company spokesperson saying Yahoo was “aware” a hacker was selling login details for 200 million Yahoo accounts in an online black market.
But more than a month later, the company filed a document with U.S. financial regulators saying it didn’t know of any claims of “unauthorized access” that might have an effect on its pending sale to Verizon. And Verizon said publicly that it had heard about the breach only two days before Yahoo announced it to the world.
All those events, of course, were years after the breach had actually happened. This is an uncommonly long delay. According to a recent report from network security firm FireEye, in 2015 the median amount of time an organization’s network was compromised before the breach was discovered was 146 days.
That includes all sizes of companies in all types of business. As a major internet company with an extremely large user base, it’s reasonable to expect Yahoo might detect – and disclose – breaches much sooner than other firms.
The company has said it believes the attack was conducted by a national government, though it hasn’t said from what country. That may suggest the attack was more sophisticated, and therefore harder to detect – but it’s impossible to know if that’s true, because the company has declined to offer details of how the breach was achieved.
In addition, anyone on the internet can claim anything they want – companies have to investigate their systems to find out whether someone who is advertising they have login information for sale actually took anything, or is just making it up to cause trouble.
Nontechnical reasons that Yahoo took so long to discover the hack could include frequent changes in leadership of its security team and the companywide stress of finding a buyer.
Once a company has learned it has been hacked, it’s important to tell customers – and the public – so that people can take proper measures to protect their information, privacy and identities.
At present there is no federal law regarding when companies must tell the public about information security breaches. In 2015, Democratsproposed giving firms 30 days from discovering a hack to announcing it had happened. That effort failed because many states, which have varying requirements, have stricter standards that the federal law would have overruled.
Tech companies can typically recover quickly from data breaches – if they respond fast and take the necessary steps to notify their users. That’s true even for corporations whose data breaches resulted in the compromise of customers’ credit card information, such as Target in 2013 and Home Depot in 2014.
Lawsuits filed after the breaches have cost companies millions in settlement costs, not to mention legal fees and lost business. The lesson is clear: Early disclosure of a data breach is better. If Yahoo knew about its hack as early as August – or even years ago – and took this long to announce it to the public, the company has manifestly betrayed its users’ trust.
Though Yahoo urged users to change their passwords and security questions after the public disclosure of the security breach, thousands of users took to social media to express anger that it had taken the company two years to uncover the data breach. The lawsuits filed against Yahoo are mounting.
It can be extremely difficult for companies, even tech-focused ones like Yahoo, to protect themselves from skilled and determined hackers. But not reporting the attack as soon as it’s suspected can be almost as damaging as the hack itself.
Yanfang Ye, Assistant Professor of Computer Science and Electrical Engineering, West Virginia University
This article was originally published on The Conversation.
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Photos/Video: ABU student makes drone as final year project, names it "Hope For Chibok Girls"


 A Physics student of Ahmadu Bello University (ABU) Shettima Ali Kyari made a drone as his final year project and named it 'Hope For Chibok Girls." Nice! More photos after the cut.
 A Physics student of Ahmadu Bello University (ABU) Shettima Ali Kyari made a drone as his final year project and named it 'Hope For Chibok Girls." Nice! More photos after the cut.


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